abstract：PURPOSE:Antagonism of norepinephrine reuptake is now an important pharmacological strategy in the treatment of anxiety and depressive disorders, and many antidepressants have substantial potential occupancy of the norepinephrine transporter (NET) at recommended dosages. Despite the importance of understanding this tran...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Severance AJ,Milak MS,Kumar JSD,Prabhakaran J,Majo VJ,Simpson NR,Van Heertum RL,Arango V,Mann JJ,Parsey RV

更新日期：2007-05-01 00:00:00

abstract：PURPOSE:We compared the prognostic value of 99mTc-tetrofosmin single-photon emission computed tomography (SPECT) after nitrate administration and positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) in patients with ischaemic left ventricular (LV) dysfunction. METHODS:Eighty-nine patients with previous...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Sorrentino AR,Acampa W,Petretta M,Mainolfi C,Salvatore M,Cuocolo A

更新日期：2007-04-01 00:00:00

abstract：INTRODUCTION:The precise clinical utility of lung 201Tl uptake in exercise SPECT myocardial perfusion imaging remains open to research. This study validates an optimal index for lung 201Tl uptake measurement and assesses its value in the prediction of higher-risk coronary artery disease (CAD). METHOD:Three hundred and...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Moralidis E,Spyridonidis T,Arsos G,Anagnostopoulos C

更新日期：2007-04-01 00:00:00

abstract：PURPOSE:Recurrences are frequent in thyroid cancer patients and long-term follow-up is therefore necessary. We evaluated the yield of rhTSH stimulation in three groups of patients, classified according to the UICC/TNM risk stratification and the results of first follow-up testing. METHODS:The study population comprise...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Zanotti-Fregonara P,Khoury A,Duron F,Keller I,Christin-Maître S,Kiffel T,Toubert ME,Devaux JY,Hindié E

更新日期：2007-04-01 00:00:00

abstract：PURPOSE:Iterative reconstruction methods based on ordered-subset expectation maximisation (OSEM) has replaced filtered backprojection (FBP) in many clinical settings owing to the superior image quality. Whether OSEM is as accurate as FBP in quantitative positron emission tomography (PET) is uncertain. We compared the a...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Søndergaard HM,Madsen MM,Boisen K,Bøttcher M,Schmitz O,Nielsen TT,Bøtker HE,Hansen SB

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:Although resynchronisation therapy (CRT) is a promising addition to heart failure therapy, a substantial number of patients do not respond to CRT. As FDG PET has routinely been used for prediction of improvement after revascularisation in ischaemic cardiomyopathy, it was hypothesised that there is also a relati...

journal_title：European journal of nuclear medicine and molecular imaging

authors： van Campen CM,Visser FC,van der Weerdt AP,Knaapen P,Comans EF,Lammertsma AA,de Cock CC,Visser CA

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:To evaluate, in patients with chest pain, the diagnostic value of ST elevation (STE) in lead aVR during stress testing prior to (99m) Tc-sestamibi scanning correlating ischaemic territory with angiographic findings. METHODS:Consecutive patients attending for (99m) Tc-sestamibi myocardial perfusion imaging (MPI...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Neill J,Shannon HJ,Morton A,Muir AR,Harbinson M,Adgey JA

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:Low sensitivity can become a major problem when very small pinholes are used in SPECT imaging. Although a larger pinhole aperture will improve the sensitivity, this will be at the cost of the spatial resolution. With a view to improving the resolution-sensitivity trade-off, this paper explores an iterative reco...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Vanhove C,Andreyev A,Defrise M,Nuyts J,Bossuyt A

更新日期：2007-02-01 00:00:00

abstract：:The 2006 EANM Congress, held in Athens, Greece, was once again a major event in the nuclear medicine scientific and educational calendar. The scientific programme, which included the second biennial ISRTRD meeting, confirmed the major developments taking place in (1) the diagnostic and prognostic uses of nuclear medic...

journal_title：European journal of nuclear medicine and molecular imaging

authors： McKillop JH,Martin-Comin J,Knapp FF Jr,Britten AJ

更新日期：2007-02-01 00:00:00

abstract：PURPOSE:The purpose of this study was to investigate the accumulation of FDG in immunocompetent patients with primary central nervous system (CNS) lymphoma using qualitative and quantitative PET images and to compare baseline with follow-up PET after therapy. METHODS:Twelve immunocompetent patients with CNS lymphoma w...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Nishiyama Y,Yamamoto Y,Monden T,Sasakawa Y,Kawai N,Satoh K,Ohkawa M

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to analyse the impact of FDG-PET staging on treatment results of neo-adjuvant radiochemotherapy in patients with advanced non-small cell lung cancer (NSCLC). We compared prospectively the outcome of two patient groups with stage III NSCLC undergoing the same neo-adjuvant radio-chemothe...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Eschmann SM,Friedel G,Paulsen F,Reimold M,Hehr T,Scheiderbauer J,Budach W,Kotzerke J,Bares R

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:Age-related values of (123)I-orthoiodohippurate (OIH) single kidney clearance rate (Cl) were estimated in a large cohort of likely normal children aged between 0 and 18 years. METHODS:Among 4,111 children examined in the past 10 years, 917 were selected with the following inclusion criteria: (a) mild ultrasono...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Imperiale A,Olianti C,Comis G,La Cava G

更新日期：2006-12-01 00:00:00

abstract：PURPOSE:A technique is described for accurate quantification of the specific binding ratio (SBR) in [(123)I]FP-CIT SPECT brain images. METHODS:Using a region of interest (ROI) approach, the SBR is derived from a measure of total striatal counts that takes into account the partial volume effect. Operator intervention i...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Tossici-Bolt L,Hoffmann SM,Kemp PM,Mehta RL,Fleming JS

更新日期：2006-12-01 00:00:00

abstract：PURPOSE:Quantitative image reconstruction in positron emission tomography (PET) requires an accurate attenuation map of the object under study for the purpose of attenuation correction. Current dual-modality PET/CT systems offer significant advantages over stand-alone PET, including decreased overall scanning time and ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ay MR,Zaidi H

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:For the assessment of folate-based radiopharmaceuticals, human nasopharyngeal KB carcinoma cells are traditionally used although nasopharyngeal cancer is rare. On the other hand, the folate receptor (FR) is frequently overexpressed on diverse cancer types, the highest frequency (>90%) being on ovarian carcinoma...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Müller C,Schubiger PA,Schibli R

更新日期：2006-10-01 00:00:00

abstract：PURPOSE:In vivo quantification of radiopharmaceuticals has great potential as a tool in developing new drugs. We investigated the accuracy of in vivo quantification with multi-pinhole single-photon emission computed tomography (SPECT) in rats. METHODS:Fifteen male Lewis rats with different stages of renal dysfunction ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Forrer F,Valkema R,Bernard B,Schramm NU,Hoppin JW,Rolleman E,Krenning EP,de Jong M

更新日期：2006-10-01 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate and compare, by means of dynamic PET, the pharmacokinetics of 68Ga-DOTATOC, a tracer which reflects the expression of somatostatin receptors (SSTRs), and of [18F]FDG, a marker of tumour viability, in patients with metastatic neuroendocrine tumours (NETs) in whom 90Y-DOT...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Koukouraki S,Strauss LG,Georgoulias V,Eisenhut M,Haberkorn U,Dimitrakopoulou-Strauss A

更新日期：2006-10-01 00:00:00

abstract：PURPOSE:In single-photon emission computed tomography (SPECT) of the dopaminergic system, measurements of striatal uptake are useful for diagnosis and patient follow-up but are strongly biased by the partial volume effect (PVE). We studied whether PVE correction might improve patient classification based on binding pot...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Soret M,Koulibaly PM,Darcourt J,Buvat I

更新日期：2006-09-01 00:00:00

abstract：PURPOSE:The purpose of this study was to map treatment-induced (99m)Tc-Hynic-rh-annexin V uptake in normal tissues using co-registration of SPECT and CT. METHODS:Nineteen patients (11 male, 8 female, mean age 57 years) with various malignant tumours (12 lymphomas, four non-small cell lung cancers and three head and ne...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kartachova MS,Valdés Olmos RA,Haas RL,Hoebers FJ,van den Brekel MW,van Zandwijk N,Herk Mv,Verheij M

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:The dopamine transporter (DAT) is a plasma membrane protein of central interest in the pathophysiology of neuropsychiatric disorders and is known to be a target for psychostimulant drugs. [(11)C]PE2I is a new radioligand which binds selectively and with moderate affinity to central DAT, as has been demonstrated...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Jucaite A,Odano I,Olsson H,Pauli S,Halldin C,Farde L

更新日期：2006-06-01 00:00:00

abstract：PURPOSE:This study was conducted to investigate whether( 18)F-fluorodeoxyglucose (FDG) uptake, quantified by positron emission tomography (PET), correlates with histological variables including tumour grade, cell proliferation, cell cycle control integrity and glucose metabolism in patients with bone and soft tissue sa...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Tateishi U,Yamaguchi U,Seki K,Terauchi T,Arai Y,Hasegawa T

更新日期：2006-06-01 00:00:00

abstract：PURPOSE:The purpose of this study was to monitor the metabolic effects of temozolomide (TMZ) chemotherapy in malignant gliomas by means of repeated positron emission tomography (PET) with [(11)C]methionine (MET). METHODS:Fifteen patients with histologically proven malignant glioma were treated by TMZ chemotherapy. MET...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Galldiks N,Kracht LW,Burghaus L,Thomas A,Jacobs AH,Heiss WD,Herholz K

更新日期：2006-05-01 00:00:00

abstract：PURPOSE:The purpose of this study was to design a fully automatic computer-assisted diagnostic system for early- and late-onset mild Alzheimer's disease (AD). METHODS:Glucose metabolic images were obtained from mild AD patients and normal controls using positron emission tomography (PET) and( 18)F-fluorodeoxyglucose (...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ishii K,Kono AK,Sasaki H,Miyamoto N,Fukuda T,Sakamoto S,Mori E

更新日期：2006-05-01 00:00:00

abstract：PURPOSE:Although polyphosphonates (PPs) were introduced as bone imaging agents in nuclear medicine in the early 1970s, the mechanisms involved in their uptake still remain unclear. Suggested mechanisms range from mineral adsorption with disputed binding to the organic phase, over incorporation into the mineralisation p...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Toegel S,Hoffmann O,Wadsak W,Ettlinger D,Mien LK,Wiesner K,Nguemo J,Viernstein H,Kletter K,Dudczak R,Mitterhauser M

更新日期：2006-04-01 00:00:00

abstract：PURPOSE:Familial adenomatous polyposis (FAP) is characterised by colonic and duodenal adenomatous polyps that carry a risk of malignant transformation. Malignant degeneration of duodenal adenomas is difficult to detect. We speculated that 2-((18)F)-fluoro-2-deoxy-D: -glucose positron emission tomography (FDG-PET) might...

journal_title：European journal of nuclear medicine and molecular imaging

authors： van Kouwen MC,Drenth JP,van Krieken JH,van Goor H,Friederich P,Oyen WJ,Nagengast FM

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:Inter-institution reproducibility of gated SPECT quantification based on institutional preferences was evaluated. This sort of variability is crucial for a multicentre study when many hospitals are involved. METHODS:A total of 106 institutes participated in this study and were grouped according to their use of...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Nakajima K,Nishimura T

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:Alzheimer's disease (AD) is a primary degenerative disease that progressively affects all brain functions, with devastating consequences for the patient, the patient's family and society. Rest regional cerebral blood flow (rCBF) could have a strategic role in differentiating between AD patients and normal contr...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Sundström T,Elgh E,Larsson A,Näsman B,Nyberg L,Riklund KA

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:The purpose of this study was to undertake dual assessment of tumour blood flow and glucose metabolism in non-small cell lung cancer (NSCLC) using contrast-enhanced computed tomography (CE-CT) and (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) in order to assess how the relationships between th...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Miles KA,Griffiths MR,Keith CJ

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:The presence of lymph node involvement (N) and distant metastasis (M) in patients with invasive bladder carcinoma is a major determinant of survival and, therefore, a pivotal element in the therapeutic management. The aim of this prospective study was to evaluate the use of( 18)F-fluorodeoxyglucose positron emi...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Drieskens O,Oyen R,Van Poppel H,Vankan Y,Flamen P,Mortelmans L

更新日期：2005-12-01 00:00:00

abstract：:The introduction of multislice computed tomography (MSCT) has allowed non-invasive coronary angiography. Although widely applied, extensive information on technical details of the technique is lacking. This survey offers detailed information on patient preparation, data acquisition, reconstruction and interpretation. ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Cademartiri F,Schuijf JD,Mollet NR,Malagutti P,Runza G,Bax JJ,de Feyter PJ

更新日期：2005-11-01 00:00:00

abstract：PURPOSE:An image-based scatter correction (IBSC) method was developed to convert scatter-uncorrected into scatter-corrected SPECT images. The purpose of this study was to validate this method by means of phantom simulations and human studies with 99mTc-labeled tracers, based on comparison with the conventional triple e...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Shidahara M,Watabe H,Kim KM,Kato T,Kawatsu S,Kato R,Yoshimura K,Iida H,Ito K

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:Radionuclide renography with angiotensin converting enzyme (ACE) inhibition plays an important role in the diagnosis of haemodynamically significant renal artery stenosis. Angiotensin receptor antagonists inhibit the renin angiotensin system at different levels from ACE inhibitors by selectively blocking the bi...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Günay EC,Oztürk MH,Ergün EL,Altun B,Salanci BV,Uğur O,Cil B,Hekimoğlu B,Caner B

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:An effective pretargeting strategy was developed for renal cell carcinoma (RCC) based on a biologically produced bispecific monoclonal antibody: anti-RCCxanti-DTPA(In) (bsMAb: G250xDTIn-1). Tumour uptake of a (111)In-labelled bivalent peptide after pretargeting with bsMAb G250xDTIn-1 was relatively high compare...

journal_title：European journal of nuclear medicine and molecular imaging

authors： van Schaijk FG,Boerman OC,Soede AC,McBride WJ,Goldenberg DM,Corstens FH,Oosterwijk E

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:Genes encoding for intracellular enzymes or transmembrane proteins are suitable as reporters, but may differ in terms of applicability for cardiac imaging. The aim of this study was to compare the human sodium iodide symporter gene (hNIS) with the herpes simplex virus type 1 thymidine kinase gene (HSV1-tk) as t...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Miyagawa M,Anton M,Wagner B,Haubner R,Souvatzoglou M,Gansbacher B,Schwaiger M,Bengel FM

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:The aim of this study was to define the impact of the presence of axillary nodal metastases on lymphatic mapping and sentinel lymph node (SLN) identification rate in patients with early breast cancer. METHODS:Two hundred and forty-six lymphatic mapping procedures were performed with both labelled nanocolloid a...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Pelosi E,Ala A,Bellò M,Douroukas A,Migliaretti G,Berardengo E,Varetto T,Bussone R,Bisi G

更新日期：2005-08-01 00:00:00

abstract：PURPOSE:Prostate cancer is difficult to visualise in its early stages using current imaging technology. The present study aimed to clarify the utility of 11C-choline PET for localising and evaluating cancer lesions in patients with prostate cancer by conducting a prospective comparison with magnetic resonance (MR) imag...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Yamaguchi T,Lee J,Uemura H,Sasaki T,Takahashi N,Oka T,Shizukuishi K,Endou H,Kubota Y,Inoue T

更新日期：2005-07-01 00:00:00

abstract：PURPOSE:Percutaneous transluminal coronary angioplasty (PTCA) is one of the main therapy options for patients with coronary artery disease (CAD), resulting in an improvement in myocardial perfusion and exercise capacity. Nevertheless, studies have also demonstrated a positive effect of regular exercise training on myoc...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kendziorra K,Walther C,Foerster M,Möbius-Winkler S,Conradi K,Schuler G,Sabri O,Hambrecht R,Kluge R

更新日期：2005-07-01 00:00:00

abstract：PURPOSE:The intra-arterial administration of 90Y microspheres is a new palliative treatment option for unresectable liver metastases. The aim of this study was to quantitatively assess changes in FDG uptake and tumour size following 90Y microsphere treatment (SIR-Spheres) using 18F-fluorodeoxyglucose (FDG) PET/CT imagi...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Bienert M,McCook B,Carr BI,Geller DA,Sheetz M,Tutor C,Amesur N,Avril N

更新日期：2005-07-01 00:00:00

abstract：UNLABELLED:The aim of this study was to evaluate the feasibility of using [(18)F] 3'-deoxy-3'-fluorothymidine (FLT) positron emission tomography (PET) for the diagnosis and grading of brain tumors. METHODS:The patient population comprised 26 patients (15 males, 11 females) with brain tumors (n=18) or nontumorous lesio...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Choi SJ,Kim JS,Kim JH,Oh SJ,Lee JG,Kim CJ,Ra YS,Yeo JS,Ryu JS,Moon DH

更新日期：2005-06-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the differential uptake of O-(2-[18F]fluorethyl)-L-tyrosine (FET) in suspected primary brain tumours. METHODS:Positron emission tomography (PET) was performed in 44 patients referred for the evaluation of a suspected brain tumour. Acquisition consisted of four 10-min frame...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Weckesser M,Langen KJ,Rickert CH,Kloska S,Straeter R,Hamacher K,Kurlemann G,Wassmann H,Coenen HH,Schober O

更新日期：2005-04-01 00:00:00